Name : Y ew bark extract ActiveIngredient : Paclitaxel Specification: 98%99%(HPLC) CAS: 33069-62-4 MolecularFormular: C47H51NO14 MolecularWeight: 264.36 Appearance: Whitecrystallinepowder Paclitaxelisamitoticinhibitorusedincancerchemotherap...

Name: Yew bark extract 

Active Ingredient:Paclitaxel

Specification:98% 99% (HPLC) 

CAS:33069-62-4 

Molecular Formular:C47H51NO14

Molecular Weight:264.36

Appearance:White crystalline powder

Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a US National Cancer Institute 

program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the

 bark of the Pacific yew tree, Taxus brevifolia and named it taxol. Later it was discovered that endophytic fungi in the 

bark synthesize paclitaxel.Paclitaxel is used to treat patients with lung, ovarian, breast, head and neck cancer, and

 advanced forms of Kaposi's sarcoma. Paclitaxel is also used for the prevention of restenosis.
Paclitaxel stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell 

division. Together with docetaxel, it forms the drug category of the taxanes. It was the subject of a notable total

 synthesis by Robert A. Holton. 

Certificate of Analysis

Product Name	Yew bark extract Paclitaxel		other Name	Taxol
Part of used	Bark		Form	Powder
Appearance	White crystalline powder		Specification	98%,98%
MOQ	1kg		Application	Healthy Products
Loss on drying	<3.0%		Testing Method	TLC/HPLC
Item		Specification		Result
Appearance		White crystalline powder		Complies
Related substance (HPLC)		Total impurity ≤0.5% Max single impurity ≤0.1%		0.2% 0.06%
Odor		Characteristic		Complies
Assay		98%		98.22%
Heavy Metal		<10ppm		Complies
As		<0.1ppm		0.05ppm
Pb		<0.1ppm		0.05ppm
Cd		<0.1ppm		0.05ppm
Residual Solvents		<100ppm		Complies
Residual Pesticide		Negative		Complies
Total Plate Count		<1000cfu/g		Complies
Yeast & Mold		<100cfu/g		Complies
E.Coli		Negative		Complies
Salmonella		Negative		Complies

Functions

1, Paclitaxel is mainly applied to ovarian and breast cancer, lung cancer, colorectal cancer,melanoma,

head and neck cancer, lymphoma. Also have a certain effect on brain tumors.

2, This product is stability drugs that can promote microtubule polymerization and microtubule polymerization

3, There will be accumulated a large number of microtubules in the cells after exposure to paclitaxel, the

accumulation of microtubules interferes with cell functions, in particular, stoped cell division in mitosis,

 

blocking normal cell division.